Muscle Glucose Metabolism
نویسندگان
چکیده
Received for publication 20 July 1981 and in revised form 28 October 1981. the ability of insulin to convert glycogen synthase from its glucose-6-phosphate-dependent (D) to its glucose6-phosphate-independent (1) form. On the other hand, following exercise, insulin prevented a marked decrease in muscle glucose-6-phosphate, which could have diminished synthase activity in situ. The possibility that exercise enhanced the ability of insulin to convert glycogen synthase D to an intermediate form of the enzyme, more sensitive to glucose-6-phosphate, remains to be explored. These results suggest that following exercise, glucose transport and glycogen synthesis in skeletal muscle are enhanced due at least in part to an increase in insulin sensitivity. They also suggest that this increase in insulin sensitivity occurs predominantly in muscle fibers that are deglycogenated during exercise.
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Regulation of glucose transport in human skeletal muscle.
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